EVALUATION OF CHRYSOPHYLLUM ALBIDUM (G. DON) FRUIT GUM AS A SUSTAINED RELEASE MATRIX IN TABLET FORMULATIONS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The goal of designing sustained release or controlled release delivery system is to reduce the frequency of dosing or to increase effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. Natural gums and polymers have been employed as excipients in modified release dosage forms. The objectives of this study were to extract and determine the percentage yield of Chrysophyllum albidum gum, perform physicochemical studies and preliminary phytochemical screening, determine the compatibility of the gum with the active ingredients, formulate sustained release tablets with the gum as the sustaining matrix and compare the release profiles with those of a standard matrix former, hydroxyl propyl methyl cellulose (HPMC), and to determine the release mechanisms and kinetics of the formulations. A percentage yield of 18 ± 4 % w /w was obtained. The gum showed physicochemical properties consistent with natural gums employed as pharmaceutical excipients. Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy studies did not show any incompatibility with chlorpheniramine maleate and theophylline hydrochloride. Tablet parameters were within pharmacopoeial limits. Dissolution studies showed an increase in retardation of drug release with increase in Chrysophylum albidum fruit gum (CAG) concentration. Batches containing 30 % CAG showed the most desirable T50% of approximately 12 h. Comparison with HPMC at the same concentration showed that CAG had better sustained release properties. Studies of the kinetics and mechanisms of drug release from CAG batches showed that at higher concentrations, the formulations demonstrated a super case II release kinetics. The mechanism of release combines swelling, erosion, and diffusion. Stability studies vii performed on the tablets after one year showed only slight changes in the T50% with no significant change in the drug content and the disintegration times. In conclusion, CAG possesses good pharmaceutical yield and tablets have good pharmacotechnical properties. Varying concentrations of CAG can be employed as a sustaining matrix in the formulation of chlorpheniramine and theophylline sustained release tablets.
Related Project Materials
CORPORATE GOVERNANCE AND ITS IMPACT ON THE MANAGEMENT OF MTN MOBILE COMMUNICATION NIGERIA LTD. KADUNA MAIN BRANCH
Abstract
This research work examine the impact of corporate governance and management of organization a case study of MT...
NUTRIENT UTILISATION AND GROWTH PERFORMANCE OF CLARIAS GARIEPINUS FED DIFFERENTLY PROCESSED MUCUNA UTILIS MEALS AS A REPLACEMENT FOR SOYBEAN-BASED DIET
ABSTRACT
High cost of feed and competition between fish and other livestock‟s feed industries necessitate research into low cost, non-con...
GLOBALIZATION AND ECONOMIC DEVELOPMENT IN NIGERIA: AN ASSESSMENT
ABSTRACT
The main aim of the research project dwells on Globalization and Economic Development in Nigeria an Assessment...
PROBLEMS OF FACILITIES MANAGEMENT IN CORPORATE ORGANIZATIONS
ABSTRACT
Facilities management in Nigeria is still in an early learning cycle when compared with the situation in E...
EVALUATION OF THE GASTROPROTECTIVE AND SUB-CHRONIC TOXICITY OF METHANOL STEM BARK EXTRACT OF XIMENIA AMERICANA LINN (OLACACEAE) IN MALE WISTAR RATS
Abstract
Ximenia americana is a plant used traditionally in northern parts of Nigeria for treatment of leprotic ulcers and mouth ulcers i...
THE COLLAPSE OF RESIDENTIAL BUILDINGS IN NIGERIA: ITS CAUSES, ITS EFFECTS, AND POSSIBLE SOLUTIONS
ABSTRACT
This study was carried out on the collapse of residential buildings in nigeria: its causes, i...
THE IMPACT OF VALUE ADDED TAX ON THE PRODUCTIVITY OF MANUFACTURING ORGANISATIONS IN THE NIGERIAN ECONOMY
Abstract
This is a study on the Impact Of Value Added Tax On The Productivity Of Manufacturing Organisations In The Nige...
INFLUENCEOF INSTRUCTIONAL SUPERVISORY ROLE OF PRINCIPALS ON TEACHERS PERFORMANCE IN PRIVATE SECONDARY SCHOOLS IN KADUNA STATE, NIGERIA
ABSTRACT
The study investigated the “Influence of Instructional Supervisory Role Performance of Principals on teachers performance...
PRODUCTION AND PERFORMANCE EVALUATION OF BIODEGRADABLE GREASE (BIOGREASE) FROM Balanites aegyptiaca (DESERT DATE) SEED OIL
ABSTRACT
This work focused on the production and testing of biodegradable grease from Balanites aegyptiaca seed kernel oil. This was carr...
EDUCATIONAL DEVELOPMENT IN BORNO STATE (A STUDY OF MAIDUGURI METROPOLITAN COUNCIL)
BACKGROUND OF THE STUDY
Education is one of the tools used to achieve a society’s goal towards de...
